The components in e-liquid are very well known and are already used in many food and household products. They are FDA approved pharmaceutical grade (USP) or food grade PG and VG and are safe to use. E-Liquids can contain nicotine and should only be used and handled by adults 18+ or 21+ or older depending on state laws. Please be aware that nicotine is a known poison and a stimulant. E-liquid should never be handled by anyone underage and should only be used by people who are smokers and have a tolerance for nicotine. In small concentrations such as 24mg and below, e-liquid is very safe. Should any amount get on your skin, simply wash away with soap and water.